Re: Insulinocytotrophic effect of Leptin

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INSÄNT AV Md. Shahidul Islam DEN 16 :e NOVEMBER, 1998 vid 10 - tiden

SOM REPLIK PÅ: Insulinocytotrophic effect of Leptin INSÄNT AV Md. Shahidul Islam DEN 06 :e MARS, 1998 vid 15 - tiden

Leptin programs the fetus? (Leptin exerts a trophic effect on fetal pancreatic islets. Riksstämman 1998 hålls i Göteborg den 24-26 november!
OBS! tisdag - torsdag. se vidare..http://www.svls.se/rskatalog/index.html). We find that leptin exerts a trophic effect on pancreatic islets
of rats even during their intrauterine period of development. We find that these fetal islets express functional leptin receptors and that
leptin can stimulate proliferation of fetal islet cells. These observations may have far-reaching implications. Thus leptin level during
intrauterine development may program the fetus as to the anticipated nutritional abundance on birth. Mothers who are too lean are likely
to give birth to babies that has a smaller islet cell mass which may predispose them to type two diabetes in later life.



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