INSÄNT AV Bidrag till Red DiabetologNytt DEN 18 :e JANUARI, 1997 vid 13 - tiden
In IDDM, Beta Cells In Inflamed Pancreatic Islets Die By Apoptosis
Researchers have shown for the first time that, in
autoimmune diabetes, beta cells in inflamed islets die by apoptosis.
In the January 7 issue of the Proceedings of the National Academy of Sciences,
Dr. Jonathan D. Katz and colleagues at Washington University School of Medicine
in St. Louis explain, "Insulin-dependent diabetes mellitus results from T
cell-mediated destruction of insulin-producing, pancreatic islet [beta cells, but
how] this destruction takes place has remained elusive."
Dr. Katz explains further that study of this destruction process has been difficult
because its natural progression is so slow. He and his colleagues developed a
"robust and accelerated [mouse] model of diabetes."
"[T]his mouse develops a rapid diabetes, which has allowed us to record and
quantify [beta] cell death," Dr. Katz writes. "We have determined that the [beta]
cells within the inflamed islets die by apoptosis." Dr. Katz told Reuters Health,
"This is the first evidence that the lymphocyte infiltration in this disease is directly
responsible for the cell death. It's not a necrotic death, not a hypoxic death, but
largely an immune response."
Dr. Katz concludes, "Having determined how [beta] cells die...we are now
capable of determining how apoptosis is induced, which should allow us to
eventually intercede in this process."
Proc Natl Acad Sci USA 1997;94:213-218.
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